Browsing Kristiania Open Archive by Author "Melheim, Maria"
Now showing items 1-1 of 1
-
MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition
Solberg, Nina; Melheim, Maria; Strand, Martin Frank; Olsen, Petter Angell; Krauss, Stefan (Journal article; Peer reviewed, 2019-02-01)The majority of colorectal cancers are induced by subsequent mutations in APC and KRAS genes leading to aberrant activation of both canonical WNT and RAS signaling. However, due to induction of feedback rescue mechanisms ...