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dc.contributor.authorVoldsbekk, Irene
dc.contributor.authorKjelkenes, Rikka
dc.contributor.authorWolfers, Thomas
dc.contributor.authorDahl, Andreas
dc.contributor.authorLund, Martina Jonette
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorFernandez-Cabello, Sara
dc.contributor.authorde Lange, Ann-Marie Glasø
dc.contributor.authorTamnes, Christian Krog
dc.contributor.authorAndreassen, Ole
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorAlnæs, Dag
dc.date.accessioned2023-09-18T13:45:31Z
dc.date.available2023-09-18T13:45:31Z
dc.date.created2023-02-21T17:06:17Z
dc.date.issued2023
dc.identifier.citationDevelopmental Cognitive Neuroscience, 2023. 60.en_US
dc.identifier.issn1878-9293
dc.identifier.urihttps://hdl.handle.net/11250/3090164
dc.description.abstractBackground Abnormalities in brain structure are shared across diagnostic categories. Given the high rate of comorbidity, the interplay of relevant behavioural factors may also cross these classic boundaries. Methods We aimed to detect brain-based dimensions of behavioural factors using canonical correlation and independent component analysis in a clinical youth sample (n = 1732, 64 % male, age: 5–21 years). Results We identified two correlated patterns of brain structure and behavioural factors. The first mode reflected physical and cognitive maturation (r = 0.92, p = .005). The second mode reflected lower cognitive ability, poorer social skills, and psychological difficulties (r = 0.92, p = .006). Elevated scores on the second mode were a common feature across all diagnostic boundaries and linked to the number of comorbid diagnoses independently of age. Critically, this brain pattern predicted normative cognitive deviations in an independent population-based sample (n = 1253, 54 % female, age: 8–21 years), supporting the generalisability and external validity of the reported brain-behaviour relationships. Conclusions These results reveal dimensions of brain-behaviour associations across diagnostic boundaries, highlighting potent disorder-general patterns as the most prominent. In addition to providing biologically informed patterns of relevant behavioural factors for mental illness, this contributes to a growing body of evidence in favour of transdiagnostic approaches to prevention and intervention.en_US
dc.language.isoengen_US
dc.subjectPsychopathologyen_US
dc.subjectYouthen_US
dc.subjectsocial communicationen_US
dc.subjectcognitive abilityen_US
dc.subjectbrain-behaviour associationsen_US
dc.titleShared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundariesen_US
dc.title.alternativeShared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundariesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.volume60en_US
dc.source.journalDevelopmental Cognitive Neuroscienceen_US
dc.identifier.doi10.1016/j.dcn.2023.101219
dc.identifier.cristin2127962
dc.source.articlenumber101219en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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